Rabbit Secondary Antibodies
ABclonal Technology 647 Rabbit anti-Human CD200R
This gene encodes a receptor for the OX-2 membrane glycoprotein Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner Alternative splicing of this gene results in multiple transcript variants
ABclonal Technology DLX3 Rabbit mAb
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll) a gene expressed in the head and limbs of the developing fruit fly The Distal-less (Dlx) family of genes comprises at least 6 different members DLX1-DLX6 Trichodentoosseous syndrome (TDO) an autosomal dominant condition has been correlated with DLX3 gene mutation This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17 Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism
Abcam Rabbit F(ab')2 Anti-Mouse IgG - H&L (Biotin), pre-adsorbed.
Rabbit F(ab')2 Anti-Mouse IgG - H&L (Biotin), pre-adsorbed.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology PE Rabbit anti-Mouse CD40 mAb
Predicted to enable antigen binding activity protein domain specific binding activity and ubiquitin protein ligase binding activity Involved in B cell mediated immunity CD40 signaling pathway and cellular calcium ion homeostasis Acts upstream of or within several processes including defense response to other organism positive regulation of B cell activation and positive regulation of interleukin-12 production Located in external side of plasma membrane and intracellular membrane-bounded organelle Part of CD40 receptor complex Is expressed in several structures including alimentary system brain hemolymphoid system gland liver and biliary system and reproductive system Human ortholog(s) of this gene implicated in several diseases including Kawasaki disease autoimmune disease (multiple) end stage renal disease hyperimmunoglobulin syndrome (multiple) and non-Hodgkin lymphoma (multiple) Orthologous to human CD40 (CD40 molecule)
ABclonal Technology Nup107 Rabbit mAb
This gene encodes a member of the nucleoporin family The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC) All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized
ABclonal Technology UFM1 Rabbit mAb
UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 (UBE1DC1 MIM 610552) and E2-like conjugating enzyme UFC1 (MIM 610554) in a manner analogous to ubiquitylation (see UBE2M MIM 603173) (Komatsu et al 2004 [PubMed 15071506])
ABclonal Technology TOM70 Rabbit mAb
This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex This protein is involved in the import of mitochondrial precursor proteins The protein interacts with the SARS-CoV and SARS-Cov-2 ORF9b proteins
ABclonal Technology MUC16/CA125 Rabbit mAb
This gene encodes a membrane-tethered mucin protein involved in forming a protective mucous barrier on epithelial surfaces The protein has an extracellular domain at its amino terminus a large tandem repeat region rich in serines threonines and prolines and a transmembrane domain with a short cytoplasmic tail The repeat region includes SEA (Sea urchin sperm protein Enterokinase and Agrin) leucine-rich and ankyrin repeats forming the ectodomain A potential cleavage site is near an SEA module This protein is believed to protect epithelial cells from pathogens It is used as a cancer marker with higher expression linked to poorer outcomes
ABclonal Technology NKX3.1 Rabbit mAb
This gene encodes a homeobox-containing transcription factor This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue Aberrant expression of this gene is associated with prostate tumor progression Alternate splicing results in multiple transcript variants of this gene
ABclonal Technology TWF2 Rabbit mAb
The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta The encoded protein contains an actin-binding site and an ATP-binding site It is most closely related to twinfilin (PTK9) a conserved actin monomer-binding protein
ABclonal Technology CD26/DPP4 Rabbit mAb
The DPP4 gene encodes dipeptidyl peptidase 4 which is identical to adenosine deaminase complexing protein-2 and to the T-cell activation antigen CD26 It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides Dipeptidyl peptidase 4 is highly involved in glucose and insulin metabolism as well as in immune regulation This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV) and protein modeling suggests that it may play a similar role with SARS-CoV-2 the virus responsible for COVID-19
Cayman Chemical MyD88NTerm RabbIt Monclo 100uL
An inhibitor of SIK2 (IC50 50s 21.63 and 6.63 nM respectively) inhibits TNF-a secretion in RAW 264.7 cells (IC50 ~2.5 UM) and reduces phosphorylation of CRTC3 and HDAC4 in macrophages at 3 UM inhibits growth of 10 ovarian cancer cell lines (IC50s 0.8-2.6 UM) and increases sensitivity of eight of them to paclitaxel halts the cell cycle at the G2/M phase and induces apoptosis and tetraploidy in SKOV3 cells at 1 UM has an additive effect on reducing tumor growth when used in combination with paclitaxel in an ovarian cancer mouse xenograft model at 60 mg/kg per day
ABclonal Technology CYP3A4 Rabbit mAb
This gene encodes a member of the cytochrome P450 superfamily of enzymes The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol steroids and other lipids This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents This enzyme is involved in the metabolism of approximately half the drugs in use today including acetaminophen codeine cyclosporin A diazepam erythromycin and chloroquine The enzyme also metabolizes some steroids and carcinogens This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21 1 Previously another CYP3A gene CYP3A3 was thought to exist however it is now thought that this sequence represents a transcript variant of CYP3A4 Alternatively spliced transcript variants encoding different isoforms have been identified
ABclonal Technology TMEM43 Rabbit mAb
This gene belongs to the TMEM43 family Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5) also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5) Arrhythmogenic right ventricular dysplasia is an inherited disorder often involving both ventricles and is characterized by ventricular tachycardia heart failure sudden cardiac death and fibrofatty replacement of cardiomyocytes This gene contains a response element for PPAR gamma (an adipogenic transcription factor) which may explain the fibrofatty replacement of the myocardium a characteristic pathological finding in ARVC
Abcam Rabbit Anti-Mouse IgG H&L (HRP) preadsorbed.
Rabbit Anti-Mouse IgG H&L (HRP) preadsorbed.
The product is subject to the following: Abcam Restricted Use Statement